Research and Scholarly Activity

Training in research is an important part of the resident's experience at Trinity Health Livonia. Through didactic sessions, online modules, journal literature reviews, and through actual participation in one of the department’s many active investigational projects, residents are taught about interpreting the medical literature, the basics of designing ethical clinical research and writing abstracts and journal articles.

During their time in the program, each resident chooses a research project and follows it through to presentation at a meeting and preparation for submission for publication in a peer-reviewed journal article. We provide funds to travel to regional and national meetings, and our residents and faculty present research at SAEM, ACOEP, ACEP and the Midwest SAEM Regional Meetings.

Residents participate in an Annual Resident Research Forum in conjunction with other regional medical centers. Through our hospital, we have access to a full-time research coordinator, a statistician and faculty-supervision for the execution of research projects. The Emergency Medicine research interests include the use of the emergency department by seniors, geriatric depression, venous thromboembolism (VTE), trauma, and COVID with multiple publications in these areas of interest.

Our department has a dedicated research director, Daniel Keyes, MD, MPH. He served as the Editor-in-Chief for the book, "Medical Response to Terrorism: Preparedness and Clinical Practice" (Lippincott). He is active with the Society of Academic Emergency Medicine and has developed and presented several didactic sessions for them. He is a fellow of the American College of Physicians, the American College of Emergency Physicians and the American College of Medical Toxicology and has authored numerous publications in the medical literature. Dr. Keyes has created a web site that helps guide a resident through the creation of a new research project: www.CoolResearcher.com

The department enjoys the participation of a bright, motivated group of students in the Emergency Medicine Research Associates Program (EMRAP) from the University of Michigan, Dearborn and Madonna University. The program is now in its tenth year. These associates support the research program and engage patients when enrolling subjects into one of our prospective research projects. Many of these associates have also co-authored publications we have contributed to the peer-reviewed medical literature.

Current areas of research at Trinity Health Livonia include:

Trauma and fractures
Senior (geriatric) health care in the ED
Venous thromboembolism and PE
Emergency ultrasound
Research Ethics
Psychiatric emergencies
Transitions of Care between facilities
Influence of drugs on dementia
Health Services Research
Opioid treatment
HIV screening
Psychiatric lab screening
Senior head trauma

Publications

Enterohormonal and Microbiota Pathophysiology Of Obesity Blake I. Hardin¹, Daniel Keyes² In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. 2022 Feb 20. Affiliations Expand. PMID: 35201732. Bookshelf ID:. Affiliations¹ University of Michigan-Dearborn 2 Michigan State University

Incidence of Traumatic Delayed Intracranial Hemorrhage Among Patients Using Direct Oral Anticoagulants. Journal of Emergency Medicine.Valiuddin H, Calice M, Alam A, Millard J, Boehm K, Valiuddin Y, Laforest D, Ricardi R, Kaakaji R, KD. In press. J Emerg Med. 2021 June 23. PMID: 34175191
DOI: 10.1016/j.jemermed.2021.04.017
Affiliations
¹St. Mary Mercy Hospital, Livonia, Michigan.
²St. Mary Mercy Hospital, Livonia, Michigan. Electronic address: Michael.Calice@stjoeshealth.org.
³Broward Health Medical Center, Fort Lauderdale, Florida.
⁴Via College of Osteopathic Medicine, Blacksburg, Virginia.
⁵Sparrow Hospital Michigan State University, Lansing, Michigan.

Change in urban and non-urban pattern of ED use during the COVID-19 pandemic in 28 Michigan hospitals: an observational study. Daniel Keyes^{1 2 3 4}, Blake Hardin ^{2 3}, Brian Sweeney ⁵, Kerby Shedden ^{6 7} BMJ Open. 2021 Feb 5. PMID: 33550257 PMCID: PMC7925925 DOI: 10.1136/bmjopen-2020-043024
Affiliations
¹Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA keyesd@umich.edu.
²Department of Natural Sciences, University of Michigan-Dearborn, Dearborn, Michigan, USA. 3St Mary Mercy Hospital, GME Research, Livonia, Michigan, USA.
⁴Department of Emergency Medicine, St Mary Mercy Hospital, Livonia, Michigan, USA. 5Data to Intelligence (D2i), Boonton, New Jersey, USA.
⁶Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA.
⁷Department of Statistics, University of Michigan, Ann Arbor, Michigan, USA.

Delirium in Older Patients With COVID-19 Presenting to the Emergency Department. Maura Kennedy ^{1 2}, Benjamin K I Helfand ^{3 4 5}, Ray Yun Gou ⁶, Sarah L Gartaganis ⁶, Margaret Webb ⁶, J Michelle Moccia ⁷, Stacey N Bruursema ⁷, Belinda Dokic ⁷, Brigid McCulloch ⁷, Hope Ring ⁷, Justin D Margolin ¹, Ellen Zhang ⁸, Robert Anderson ⁹, Rhonda L Babine ^{9 10}, Tammy Hshieh ¹¹, Ambrose H Wong ¹², R Andrew Taylor ¹², Kathleen Davenport ¹³, Brittni Teresi ¹³, Tamara G Fong ^{6 8}, Sharon K Inouye ^{6 14} Emerg Med. 2020 Nov 2. PMID: 33211114 PMCID: PMC7677760 DOI: 10.1001/jamanetworkopen.2020.29540

Update on Neurological Manifestations of SARS-CoV-2. Hisham M Valiuddin ¹, Almir Kalajdzic ², James Rosati ², Kevin Boehm ³, Dominique Hill ² West J Emerg Med 2020 Oct 6. PMID: 33052822 PMCID: PMC7673884 DOI: 10.5811/westjem.2020.8.48839

Comparison of admission rates among patients treated by male and female emergency physicians: a multicenter study. Valiuddin H, et al. BMC Emerg Med. 2020. PMID: 32611316

Emergency Medicine in Egypt. Mohamed M, Keyes D, Abbasy M, Hammad W, Hirshon JM, Al-Fanharawi H, Haidous A, Abbas Khalifa GE.Mohamed M, et al. J Emerg Med. 2020 Jun 23:S0736-4679(20)30384-X. doi: 10.1016/j.jemermed.2020.04.046. Online ahead of print.J Emerg Med. 2020. PMID: 32591297

Rare anoxic brain injury sequela of delayed posthypoxic leukoencephalopathy due to recreational drug overdose with benzodiazepines. Kara Kaplan, Ariful Alam, Braydon Dymm, Hisham Valiuddin, Sangeetha Nanthabalan. First published: 28 February 2020. https://doi.org/10.1002/ccr3.2705. Citations: 1

Utility of INR For Prediction of Delayed Intracranial Hemorrhage Among Warfarin Users with Head Injury Hisham Valiuddin¹, Ariful Alam², Michael Calice¹, Kevin Boehm³, John Millard⁴, Daniel Laforest⁵, Yaser Valiuddin⁶, Rick Ricardi⁴, Rami Kaakaji⁷, Spencer Koch⁷, Thomas Oweis⁴, Daniel Keyes¹ PMID: 32057543 DOI: 10.1016/j.jemermed.2020.01.003
Affiliations
¹Department of Emergency Medicine, St. Mary Mercy Hospital, Livonia, Michigan.
²Department of Internal Medicine, St. Mary Mercy Hospital, Livonia, Michigan.
³Department of Emergency Medicine, Broward Health Medical Center, Fort Lauderdale, Florida.
⁴Department of Trauma Surgery, St. Mary Mercy Hospital, Livonia, Michigan.
⁵Department of Emergency Medicine, Sparrow Hospital, Michigan State University, Lansing, Michigan.
⁶Bluefield College-Via College of Osteopathic Medicine, Blacksburg, Virginia.
⁷Department of Radiology, St. Mary Mercy Hospital, Livonia, Michigan.

Acute transverse myelitis associated with SARS-CoV-2: A Case-Report. Valiuddin H, Skwirsk B, Paz-Arabo P.Valiuddin H, et al. Brain Behav Immun Health. 2020 May;5:100091. doi: 10.1016/j.bbih.2020.100091. Epub 2020 Jun 6.Brain Behav Immun Health. 2020. PMID: 32835294

The Affordable Care Act and emergency department use by low acuity patients in a US hospital Daniel Keyes¹ ², Hisham Valiuddin¹, Hassan Mouzaihem³, Patrick Stone⁴, Jaqueline Vidosh² PMID: 32883130 DOI: 10.1177/0951484820943599
Affiliations
¹St Mary Mercy Hospital, Livonia, MI, USA.
²University of Michigan Medical School, Ann Arbor, MI, USA.
³School of Medicine, Wayne State University, Dearborn Heights, MI, USA.
⁴R Adams Cowley Shock Trauma Center, Baltimore, MD, USA.

SMML Emergency Medicine Scholarly Activity

Accuracy of Dementia Screening Instruments in Emergency Medicine: A Diagnostic Meta-analysis. Carpenter CR¹, Banerjee J^2,3, Keyes D^4,5, Eagles D⁶, Schnitker L⁷, Barbic D⁸, Fowler S⁹, LaMantia MA¹⁰. Acad Emerg Med. 26(2):226-245. doi: 10.1111/acem.13573. https://onlinelibrary.wiley.com/doi/full/10.1111/acem.13573

Follow-up CT Pulmonary Angiograms in Patients with Acute Pulmonary Embolism. Stein PD¹, Matta F², Hughes PG^2,3, Hourmouzis ZN³, Hourmouzis NP³, Schweiss RE⁴, Bach JA⁴, Kazan VM⁵, Kakish EJ⁵, Keyes DC^2,4, Hughes MJ². Emerg Radiol. 23(5):463-7. doi: 10.1007/s10140-016-1422-1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102605/

First Report of Survival in Refractory Ventricular Fibrillation After Dual-Axis Defibrillation and Esmolol Administration. Boehm KM¹, Keyes DC¹, Mader LE², Moccia JM². West J Emerg Med. 17(6):762-765. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102605/

Home Treatment of Pulmonary Embolism in the Era of Novel Oral Anticoagulants. Stein PD¹, Matta F², Hughes PG³, Hourmouzis ZN⁴, Hourmouzis NP⁴, White RM⁵, Ghiardi MM⁶, Schwartz MA⁷, Moore HL⁷, Bach JA⁸, Schweiss RE⁸, Kazan VM⁷, Kakish EJ⁷, Keyes DC⁹, Hughes MJ⁵. Am J Med.129(9):974-7. doi: 10.1016/j.amjmed.2016.03.035. https://www.sciencedirect.com/science/article/pii/S0002934316304028?via%3Dihub

Home Treatment of Deep Venous Thrombosis in the Era of New Oral Anticoagulants. Stein PD¹, Matta F², Hughes PG³, Ghiardi M⁴, Marsh JH⁵, Khwarg J⁶, Brandon MS⁵, Fowkes HA⁵, Kazan V⁷, Wiepking M⁷, Keyes DC⁵, Kakish EJ⁷, Hughes MJ². Clin Appl Thromb Hemost. 21(8):729-32. doi: 10.1177/1076029615598222. https://journals.sagepub.com/doi/10.1177/1076029615598222

Mind the (Knowledge) Gap: The Effect of a Communication Instrument on Emergency Department Patients' Comprehension of and Satisfaction with Care. Simmons S¹, Sharp B², Fowler J³, Fowkes H⁴, Paz-Arabo P⁴, Dilt-Skaggs MK⁵, Singal B³, Carter T⁶. Patient Educ Couns. 98(2):257-62. doi: 10.1016. https://www.sciencedirect.com/science/article/pii/S0738399114004480?via%3Dihub